1. Hgb < 8 and Hct less than 24
2. Hgb < 9 in patient undergoing surgery or postop within 3 days with continued blood loss with active bleeding
3. > 15% blood loss (750cc)
4. Symptomatic anemia (hypovolemia and/or hypoxia) with Hbg < 10.0
5. Anemia with Hgb < 10.0 and risk factor for ischemia (CAD, cardiac valvular disease, CHF, cerebral ischemic disease)
6. Hgb < 11.0 and diagnosis of unstable angina or acute MI, age >=65

Hemoglobin < 10

1. Platelet count < 20,000
2. Platelet count < 70,000 in patient

• undergoing major surgery
• with active bleeding
• with severe trauma

Automatic review if diagnosis is Immune Thrombocytopenia(ITP) or Immune Thrombocytopenia Purpura

1. Thrombotic Thrombocytopenia Purpura
2. PT > 16 and/or PTT greater than 40 seconds

Automatic review with no prior PT or PTT (except for TTP)

1. Fibrinogen < 100 mg per mg/dl with unexpected clinical bleeding in the absence of thrombocytopenia or surgical prophylaxis
2. vonWillebrand's diease with clinical bleeding or for surgical prophylaxis
3. Hemophilia A
4. Factor XIII deficiency
5. Acquired severe coagulopathy (fibrinogen < 100 mg/dl) and clinical diagnosis of dissecting aneurysm, post-partum fibrinolysis, disseminated intravascular coagulation or severe end-stage liver disease
6. Used as fibrin glue to aid in surgical hemostasis